This website is about the hypothesis of the association of "Chronic cerebrospinal venous insufficiency" (CCSVI) and multiple sclerosis (MS). The pattern of CCSVI was described by Prof. Zamboni. We list research such as scientific publications or conference presentations and media coverage.

Pilot study of Zamboni, Zivadinov and Weinstock-Guttman published

The pilot study of the professors Zamboni, Zivadinov and Weinstock-Guttman is available.

Zamboni P, Menegatti E, Weinstock-Guttman B, Schirda C, Cox JL, Malagoni AM, Hojanacki D, Kennedy C, Carl E, Dwyer MG, Bergsland N, Galeotti R, Hussein S, Bartolomei I, Salvi F, and Zivadinov R:
The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics. [zamboni09h]

Critical Point of View in Annals of Neurology

A critical article has appeared and another one will be published in the next issue.

  • Experimental multiple sclerosis vascular shunting procedure halted at Stanford. [ana10a]
  • Point of View: Chronic cerebrospinal venous insufficiency and multiple sclerosis. [khan10a]
    • Reply of Ashton Embry: An Open Letter to the Authors of Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis (Khan et al, 2010, Annals of Neurology). PDF

Presentations Hamilton CCSVI Workshop on MS Feb 7, 2010

Presentations of "CCSVI Workshop on MS Feb 7, 2010" are available [ws_hamilton10_2]

  • Zivadinov R: CCSVI and MRI Outcomes in MS. [pres_zivadinov10a]
  • Al-Omari M, Rousan L: CCSVI: Evidence from Jordanian experience. [pres_al-omari10a]
  • Haacke EM: Is the Basic Etiology of Multiple Sclerosis Vascular in Origin? [pres_haacke10a]
  • Dake MD: Locations and etiologies of extracranial venous lesions in MS. [pres_dake10a]
  • Simka M: Preliminary results of preoperative diagnostics and endovascular treatment for CCSVI. [pres_simka10a]
  • Zamboni P: CCSVI: Implications in Multiple Sclerosis [pres_zamboni10a] new

First Blinded Study of Venous Insufficiency Prevalence in MS Shows Promising Results

Press release February 9, 2010, University at Buffalo

BUFFALO, N.Y. – More than 55 percent of multiple sclerosis patients entered in the initial phase of the first randomized clinical study to determine if persons with MS exhibit narrowing of the extracranial veins causing restriction of normal outflow of blood from the brain were found to have the abnormality, neurology researchers at the University at Buffalo have found.

When the 10.2 percent of subjects in which results were border line were excluded, the percentage of affected MS patients rose to 62.5 percent, preliminary results show, compared to 25.9 percent of healthy controls.

These preliminary results are based on the first 500 participants in the Combined Transcranial and Extracranial Venous Doppler Evaluation (CTEVD) study, which began at UB in April 2009. Investigators are planning to examine 500 additional subjects, who will be assessed in the second phase of the study with more advanced diagnostic tools. Complete data on the first 500 will be presented at the American Academy of Neurology meeting in April.

BNAC CCSVI Newsletter Volume 1 Issue 1 by Dr. Robert Zivadinov

Prof. Robert Zivadinov published a first report about the CCSVI Study of  Buffalo Neuroimaging Analysis Center (BNAC).

BNAC CCSVI Newsletter Volume 1 Issue 1, 4 Feb 2010 (PDF)

«I speak for the entire BNAC-JNI research team and Dr. Bianca Weinstock-Guttman to let you know that this particular research is having an impact like no other we have known

Consensus Document of the International Union of Phlebology (IUP) – 2009

A consensus conference on venous malformations[uip09] – headed by Prof. Byung B Lee from Georgetown – and experts from 47 countries – studied the evidence and unanimously voted in favour of officially including the stenosing lesions found in CCSVI in the new Consensus document and Guidelines.


This paper can be brought to interventional radiologists and vascular surgeons. CCSVI lesions are classified as a truncular venous malformations - which means that vascular doctors have now classified this disease, CCSVI, as congenital- and preceding MS lesions.

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