Clinical trials

A list of publications around the hypothesis of venous multiple sclerosis. The references are chronologically ordered, the latest at the top.

Table of contents 

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Clinical trials

  1. [trial_mcdonald10a] McDonald S: Double-blinded study for assessing CCSVI and its treatment. Source
  2. [trial_siddiqui10a] Siddiqui A, Levy E and Hopkins LN: Prospective Randomized Endovascular therapy in Multiple Sclerosis (PREMiSe). University at Buffalo Neurosurgery (UBNS). Source: UB, prweb.com, CTV
    University at Buffalo Neurosurgery (UBNS)
  3. [prep_epidem10a] Italian MS Foundation (FISM): Epidemiological study to confirm and extend Dr. Zamboni’s findings by evaluating the prevalence of CCSVI in healthy controls, MS and other neurodegenerative diseases. Source: msif.org
    Italian MS Foundation (FISM)
  4. [trial_zivadinov10a] Zivadinov R: Controlled Randomized EndovaScular Therapy (CRET) study for CCSVI. Sources: mastersofms.com, BNAC newsletter.
    Buffalo Neuroimaging Analysis Center (BNAC), University of Buffalo, The State University of New York
  5. [trial_cihr10a] Canadian Institute for Health Research (CIHR): Randomized, blinded clinical trial on the effect of this therapeutic approach (CCSVI). CTV Winnipeg
    Canadian Institute for Health Research (CIHR)
  6. [trial_wolinsky10a] Wolinsky J: CCSVI and its relationship to MS. University of Texas Health Science Center at Houston, USA. Info.
    University of Texas Health Science Center at Houston, USA.
  7. [trial_knox10a] Traboulsee A, Knox K, Li DKB, Machan L, Rauscher A, MacKay A, Illes J, Voll C, Wiebe S, Szkup P, Kelly M: Investigation into Venous Insufficiency in Multiple Sclerosis. MS clinic in Saskatoon, Saskatchewan, Canada. [rynor10a] Charity Intelligence Canada Report (PDF). The StarPhoenix. The Globe and Mail, CTV News, Funding granted for studies to see if blocked veins cause MS, Facebook. Info. Fact Sheet (PDF). UBC page.
    University of British Columbia MS Clinic, UBC Faculty of Medicine, MS clinic in Saskatoon, University of Saskatchewan, Canada
  8. [trial_torres10a] Torres C, Cameron IG, Hogan MJ, Schweitzer ME, Lum C, Bussière ME, Chakraborty S, Freedman MS: Chronic Cerebrospinal Venous Insufficiency in relation to Multiple Sclerosis. The Ottawa Hospital, University of Ottawa, Ontario, Canada. Info. Fact Sheet (PDF).
    The Ottawa Hospital, University of Ottawa, Ontario, Canada
  9. [trial_fox10a] Fox RJ: A Multi-Modal Assessment of Chronic Cerebrospinal Venous Insufficiency. Dr. Robert Fox Cleveland Clinic, Cleveland, USA. Info.
    Dr. Robert Fox Cleveland Clinic, Cleveland, USA.
  10. [trial_field10a] Field A: Study of CCSVI in MS using quantitative time-resolved 3D MRV. University of Wisconsin School of Medicine and Public Health, Madison, USA. Info.
    University of Wisconsin School of Medicine and Public Health, Madison, USA.
  11. [trial_costello10a] Costello F, Goyal M, Frayne R, Mah JK, Davenport J, Scott J: Determining the relationship between chronic cerebrospinal venous insufficiency (CCSVI) and multiple sclerosis (MS). Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. Info. Fact Sheet (PDF).
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta.
  12. [trial_banwell10a] Banwell B, Macgowan c, Laughlin S, Shroff M, Sled J, Yeung R, Benseler S, Traubici J, Moharir M, Arnold D, Narayanan S, Bar-Or A,Marrie RA: Cerebral Venous Hemodynamics in Pediatric Multiple Sclerosis. The Hospital for Sick Children, Toronto, Ontario, Canada. Info. Fact Sheet (PDF)
    The Hospital for Sick Children, Toronto, Ontario, Canada
  13. [trial_zamboni10b] Zamboni P: Randomised controlled CCSVI treatment trial. Source (medpage interview at 2:15)
    Italy
  14. [trial_dake10a] Dake M: CCSVI Study. Stanford University. Source (Video interview). Needs funding.
    Stanford University
  15. [trial_tornatore10a] Tornatore C, Neville R: CCSVI treatment study. Georgetown University Hospital. Source
    Georgetown University Hospital, USA
  16. [trial_sinan10a] Sinan T, Al Khashan S, Safar H, Almuzaini AA, Bin naki AM, Al bader M, Bahzad M: CCSVI study Kuwait. ccsvikuwait.com. Study description, Introduction.
    Mubarak Hospital and other Hospitals of Kuwait
  17. [trial_hubbard10a] Hubbard D: The fMRI BOLD Response in MS, Support for the CCSVI Hypothesis. Hubbard Foundation for fMRI Research. Grant Request (PDF)
    Hubbard Foundation for fMRI Research.
  18. [trial_mehta10a] Mehta M: Liberation Study - 500 person. clinicaltrials.gov: NCT01089686. Study to evaluate treating chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis patients. v-aware Vol. 2, Issue 1, March 2010, p18: Announcement. Some info.
    The Vascular Group, PLLC, Albany NY, USA.
  19. [trial_rodger10a] Rodger I, Haacke EM: St. Joe's MS study - 100 person and 100 controls. St. Joseph's Healthcare, Canada. [rynor10a] The Hamilton Spectator. Requested Grant (PDF). Charity Intelligence Canada Report (PDF). Needs funding. Donate. See also [ws_hamilton10_2]
    St. Joseph's Health Care, McMaster University and Hamilton General Hospital, Canada
  20. [trial_zamboni10a] Zamboni P, Galeotti R, Weinstock-Guttman B, Cutter G, Menegatti E, Malagoni AM, Bartolomei I, Cox JL, Salvi F, and Zivadinov R: Endovascular Treatment for Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis: A Longitudinal, Magnetic Resonance Imaging, Blinded Pilot Study. - 16 person. J Vasc Surg. 2010 Mar;51(3):794. doi:10.1016/j.jvs.2009.11.022. Abstract, PDF
    University of Ferrara, Ferrara, Italy; NY State University in Buffalo, Buffalo, NY
    Comment
    Schedule:
    1. Conclusion: October 2010
    2. Publication: Fall 2011
  21. [trial_ctevd09] Buffalo Neuroimaging Analysis Center (BNAC), New York State University (SUNY), Buffalo: Combined Transcranial and Extracranial Venous Doppler evaluation in multiple sclerosis and related diseases (CTEVD study). - 1700 person. CTEVD press release, TV news, WBFO Public Radio, Buffalo News, CTEVD Study Enrollment, Newsletter Vol 1 Issue 1, 4 Feb 2010 (PDF), Press release Feb 9, 2010
    Description

    The new study will involve 1,600 adults and 100 children. The cohort will be comprised of 1,100 patients who were diagnosed with possible or definite MS, 300 age-and-sex matched normal controls, and 300 patients with other autoimmune and neurodegenerative diseases. Enrollment in the study has begun and will continue for two years. Preliminary results will be reported in early Febrary and final results are expected in 2011.

    Schedule:
    1. Preliminary results, first 500 patients: April 2010
    2. Publication: Fall 2011

Missing trials?

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