This website is about the hypothesis of the association of "Chronic cerebrospinal venous insufficiency" (CCSVI) and multiple sclerosis (MS). The pattern of CCSVI was described by Prof. Zamboni. We list research such as scientific publications or conference presentations and media coverage.

CCSVI Examination

Personal examination/treatment

The goal of this website is to track development, especially research. CCSVI is currently under research. Examination and treatments are not standard medical methods. Access to treatment for multiple sclerosis must be based on science, not hope. Unfortunately, the research is still in the beginning. There are no scientific publications about "stenting" and thus there is no valid experience on that. Stents could be risky in the long term. A treatment in foreign countries may have additional risks. After-care examination should not be forgotten. Treatments should only be done within good scientific studies in order to increase the knowlege rapidly for everyone. See at the following presented book "Testing Treatments".

27 new publications

  1. [radak11b] Radak D, Tanaskovic S, Marinkovic S, Antonic Z, and Kolar J: Internal jugular vein duplication: a further truncular malformation in a patient with multiple sclerosis. Phlebology. 2011 Oct:. PMID 22037279, doi:10.1258/phleb.2011.011027.
    Vascular Surgery Clinic, Dedinje Cardiovascular Institute, Heroja Milana Tepića 1 Street, Belgrade, Serbia.

New upright MRI publication: Possible abnormal CSF hydrodynamics in the genesis of multiple sclerosis

  • [damadian11a] Damadian RV, and Chu D: The possible role of cranio-cervical trauma and abnormal CSF hydrodynamics in the genesis of multiple sclerosis. Physiol Chem Phys Med NMR. 2011 ;41:1-17. PMID 21970155.
    FONAR Corporation, 110 Marcus Drive, Melville, NY 11747, USA.

A second case of Marburg's variant of MS with vasculitis

Just found this article by accident on Pubmed. I've only read the Abstract. Hmm? I don't know if this is related to our topic.

  • [elenein11a] Elenein RG, Sharer LR, Cook SD, Pachner AR, Michaels J, and Hillen ME: A second case of Marburg's variant of multiple sclerosis with vasculitis and extensive demyelination. Mult Scler. 2011 Aug:. PMID 21816761, doi:10.1177/1352458511414042. new
    University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Department of Neurology, USA.

Angioplasty for MS: Patient-driven, safe, but is it effective?

An article asking the key question: Angioplasty for MS: Patient-driven, safe, but is it effective?, Cardiovascular Business, June 30, 2011

Summer publication update

Some articles were published in the first half of the year.

  1. [zaharchuk11a] Zaharchuk G, Fischbein NJ, Rosenberg J, Herfkens RJ, and Dake MD: Comparison of MR and Contrast Venography of the Cervical Venous System in Multiple Sclerosis. AJNR Am J Neuroradiol. 2011 Jul:. PMID 21757521, doi:10.3174/ajnr.A2549.
    Departments of Radiology and Cardiothoracic Surgery, Stanford University, Stanford, California; Department of Radiology, Stanford University Medical Center, Stanford, California.
  2. [waschbisch11a] Waschbisch A, Manzel A, Linker RA, and Lee DH: Vascular pathology in multiple sclerosis: mind boosting or myth busting? Exp Transl Stroke Med. 2011 Jul;3(1):7. Epub 2011 Jul 14. PMID 21756314, doi:10.1186/2040-7378-3-7.
  3. [filippi11a] Filippi M, and Rocca MA: The multiple sclerosis mystery: is there a vascular component? Lancet Neurol. 2011 Jul;10(7):597-8. PMID 21683924, doi:10.1016/S1474-4422(11)70124-7.
    Neuroimaging Research Unit, Division of Neuroscience, Scientific Institute and "Vita-Salute" University, Hospital San Raffaele, Milan, Italy.
  4. [zamboni11c] Zamboni P.: Can Facebook influence funding? Nature. 26. Mai 2011, 473(7348):452. doi:10.1038/473452e.
  5. [giampiero11a] Giampiero A: Chronic cerebrospinal venous insufficiency and susceptibility to multiple sclerosis. Ann Neurol. 2011 Jul;70(1):181. Epub 2011 Jun 14. PMID 21674590, doi:10.1002/ana.22451.
    Department of Vascular Medicine, Sant'Antonio Hospital, Padua, Italy.
  6. [lazzaro11a] Lazzaro MA, Zaidat OO, Mueller-Kronast N, Taqi MA, and Woo D: Endovascular therapy for chronic cerebrospinal venous insufficiency in multiple sclerosis. Front Neurol. 2011 ;2:44. PMID 21808631, doi:10.3389/fneur.2011.00044.
    Department of Neurology, Froedtert Hospital and Medical College of Wisconsin Milwaukee, WI, USA.
  7. [thapar11a] Thapar A, Lane TR, Pandey V, Shalhoub J, Malik O, Ellis M, Franklin IJ, Nicholas R, and Davies AH: Internal jugular thrombosis post venoplasty for chronic cerebrospinal venous insufficiency. Phlebology. 2011 Jul:. PMID 21803799, doi:10.1258/phleb.2011.011052.
    * Imperial College London.
  8. [centonze11a] Centonze D, Floris R, Stefanini M, Rossi S, Fabiano S, Castelli M, Marziali S, Spinelli A, Motta C, Garaci FG, Bernardi G, and Simonetti G: Proposed chronic cerebrospinal venous insufficiency criteria do not predict multiple sclerosis risk or severity. Ann Neurol. 2011 Jul;70(1):52-9. PMID 21786298, doi:10.1002/ana.22436.
    Department of Neuroscience, University Hospital Tor Vergata, Rome, Italy; Santa Lucia Foundation/European Center for Brain Research.
  9. [awad11a] Awad AM, Marder E, Milo R, and Stüve O: Multiple sclerosis and chronic cerebrospinal venous insufficiency: a critical review. Ther Adv Neurol Disord. 2011 Jul;4(4):231-5. PMID 21765873, doi:10.1177/1756285611405565.
    Baton Rouge Neurology Associates, Baton Rouge General Medical Center, 3600 Florida Blvd, Baton Rouge, LA 70806, USA.
  10. [fragoso11a] Fragoso YD: The internet racing ahead of the scientific evidence: the case of "liberation treatment" for multiple sclerosis. Arq Neuropsiquiatr. 2011 Jun;69(3):525-7. PMID 21755134.
    Department of Neurology, Medical School, UNIMES, Santos, SP, Brazil.
  11. [dhaeseleer11a] D'haeseleer M, Cambron M, Vanopdenbosch L, and De Keyser J: Vascular aspects of multiple sclerosis. Lancet Neurol. 2011 Jul;10(7):657-66. PMID 21683931, doi:10.1016/S1474-4422(11)70105-3.
    Department of Neurology, Universitair Ziekenhuis Brussel, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.
  12. [simka11a] Simka M: Commentary: Safety of endovascular treatment for CCSVI and future perspectives. J Endovasc Ther. 2011 Jun;18(3):326-7. Type: Comment. PMID 21679069, doi:10.1583/11-3400C2.1.
    Department of Vascular and Endovascular Surgery, Euromedic Specialist Clinics, Katowice.
  13. [Haider11a] Haider L, Fischer MT, Frischer JM, Bauer J, Höftberger R, Botond G, Esterbauer H, Binder CJ, Witztum JL, and Lassmann H: Oxidative damage in multiple sclerosis lesions. Brain. 2011 Jul;134(Pt 7):1914-24. Epub 2011 Jun 7. PMID 21653539, doi:10.1093/brain/awr128.
    Centre for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Wien, Austria.
  14. [petrov11a] Petrov I, Grozdinski L, Kaninski G, Iliev N, Iloska M, and Radev A: Safety profile of endovascular treatment for chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Endovasc Ther. 2011 Jun;18(3):314-23. PMID 21679067, doi:10.1583/11-3440.1.
    Cardiology Department, Tokuda Hospital Sofia, Bulgaria.
  15. [wattjes11a] Wattjes MP, Doepp F, Bendszus M, and Fiehler J: ["Chronic cerebrospinal venous insufficiency" in multiple sclerosis - is multiple sclerosis a disease of the cerebrospinal venous outflow system?]. Rofo. 2011 Jun;183(6):523-30. Epub 2011 Apr 12. Type: Review. PMID 21487978, doi:10.1055/s-0031-1273292.
    MS Center Amsterdam, Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands.
  16. [dake11a] Dake M.: CCSVI: What We Need to Know Now and in the Future. Endovascular Today, July 2011. Article, PDF.
  17. [siskin11a] Gary Siskin, Kenneth Mandato and Meridith Englander: Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis Patients. Endovascular Today, July 2011. Article, PDF.
  18. [ranadive11a] Ranadive SM, Yan H, Weikert M, Lane AD, Linden MA, Baynard T, Motl RW, and Fernhall B: Vascular Dysfunction and Physical Activity in Multiple Sclerosis. Med Sci Sports Exerc. 2011 Jul:. PMID 21775908, doi:10.1249/MSS.0b013e31822d7997.
    From the Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, IL.
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