This website will serve as a platform for the hypothesis of the relation between "Chronic cerebrospinal venous insufficiency" (CCSVI) and multiple sclerosis (MS). The pattern of CCSVI was described by Prof. Zamboni. This website will give an overview and track the development, especially scientific publications and media coverage. As discussion forum we recommend the CCSVI This Is MS forum.

CCSVI Video Prof. Zamboni

Last modified: 01.03.2010 - 16:05 CET Created: 01.03.2010 - simplex

Introduction to Venous Multiple Sclerosis

Last modified: 24.02.2010 - 20:42 CET Created: 20.08.2009 - simplex

  1. What is CCSVI?

    Chronic cerebrospinal venous insufficiency... it’s a chronic (ongoing) problem where blood from the brain and spine has trouble getting back to the heart. It’s caused by stenosis (a narrowing) in the veins that drain the spine and brain. Blood takes longer to get back to the heart, and it can reflux back into the brain and spine or cause edema and leakage of red blood cells and fluids into the delicate tissue of the brain and spine. Blood that stays in the brain too long creates “slowed perfusion”...a delay in deoxyginated blood leaving the head. This can cause a lack of oxygen (hypoxia) in the brain. Plasma and iron from blood deposited in the brain tissue are also very damaging.

Pilot study of Zamboni, Zivadinov and Weinstock-Guttman published

Last modified: 01.03.2010 - 14:11 CET Created: 01.03.2010 - simplex

The pilot study of the professors Zamboni, Zivadinov and Weinstock-Guttman is available.

Zamboni P, Menegatti E, Weinstock-Guttman B, Schirda C, Cox JL, Malagoni AM, Hojanacki D, Kennedy C, Carl E, Dwyer MG, Bergsland N, Galeotti R, Hussein S, Bartolomei I, Salvi F, and Zivadinov R:
The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics. [zamboni09h]

Critical Point of View in Annals of Neurology

Last modified: 01.03.2010 - 13:34 CET Created: 01.03.2010 - simplex

A critical article has appeared and another one will be published in the next issue.

  • Experimental multiple sclerosis vascular shunting procedure halted at Stanford. [ana10a]
  • Point of View: Chronic cerebrospinal venous insufficiency and multiple sclerosis. [khan10a]
    • Reply of Ashton Embry: An Open Letter to the Authors of Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis (Khan et al, 2010, Annals of Neurology). PDF

Presentations Hamilton CCSVI Workshop on MS Feb 7, 2010

Last modified: 01.03.2010 - 16:25 CET Created: 27.02.2010 - simplex

Presentations of "CCSVI Workshop on MS Feb 7, 2010" are available [ws_hamilton10_2]

  • Zivadinov R: CCSVI and MRI Outcomes in MS. [pres_zivadinov10a]
  • Al-Omari M, Rousan L: CCSVI: Evidence from Jordanian experience. [pres_al-omari10a]
  • Haacke EM: Is the Basic Etiology of Multiple Sclerosis Vascular in Origin? [pres_haacke10a]
  • Dake MD: Locations and etiologies of extracranial venous lesions in MS. [pres_dake10a]
  • Simka M: Preliminary results of preoperative diagnostics and endovascular treatment for CCSVI. [pres_simka10a]

First Blinded Study of Venous Insufficiency Prevalence in MS Shows Promising Results

Last modified: 10.02.2010 - 23:09 CET Created: 10.02.2010 - simplex

Press release February 9, 2010, University at Buffalo

BUFFALO, N.Y. – More than 55 percent of multiple sclerosis patients entered in the initial phase of the first randomized clinical study to determine if persons with MS exhibit narrowing of the extracranial veins causing restriction of normal outflow of blood from the brain were found to have the abnormality, neurology researchers at the University at Buffalo have found.

When the 10.2 percent of subjects in which results were border line were excluded, the percentage of affected MS patients rose to 62.5 percent, preliminary results show, compared to 25.9 percent of healthy controls.

These preliminary results are based on the first 500 participants in the Combined Transcranial and Extracranial Venous Doppler Evaluation (CTEVD) study, which began at UB in April 2009. Investigators are planning to examine 500 additional subjects, who will be assessed in the second phase of the study with more advanced diagnostic tools. Complete data on the first 500 will be presented at the American Academy of Neurology meeting in April.

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