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News zur venösen Multiple Sklerose / CCSVI.

New or updated research publications

Last modified: 10.10.2010 - 14:39 CET Created: 10.10.2010 - simplex

[phillips10a] Phillips LA: This Way In: CCSVI and Multiple Sclerosis. Neurology Now. Jul/Aug 2010;6(4):9-11. doi:10.1097/01.NNN.0000387765.20876.4c. Article
[alexander10a] Alexander JS, Zivadinov R, Maghzi AH, Ganta VC, Harris MK, and Minagar A: Multiple sclerosis and cerebral endothelial dysfunction: Mechanisms. Pathophysiology. 2010 Jul:. PMID 20663648, doi:10.1016/j.pathophys.2010.04.002.
Department of Cellular and Molecular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.

Abstract
Multiple sclerosis (MS) is believed to be an immune-mediated neurodegenerative disorder of the human central nervous system which usually affects younger adults with certain genetic backgrounds. The causes and cure for MS remain elusive. Based on the recent advances in our understanding of the pathogenic mechanisms of MS, it appears to represents a heterogeneous group of disorders with dissimilar pathophysiology and neuropathology. Currently, there is no unifying hypothesis to explain the pathogenesis of this complex disease. The three prevailing concepts on the pathogenesis of MS include viral, immunological, and vascular hypotheses. This review presents MS as a neuroinflammatory disease with a significant vascular component and examines the existing evidence for the role of cerebral endothelial cell dysfunction in the pathogenesis of this progressive central nervous system (CNS) inflammatory disorder.

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Offener Brief an Christian Wulff (Schirmherr DMSG) - Update 3

Last modified: 11.09.2010 - 18:31 CET Created: 18.06.2010 - simplex

Ein offener Brief eines DMSG Mitgliedes an DMSG Schirmherrn Christian Wulff wurde zur Veröffentlichung zugesandt. 9. Juni 2010:

Sehr geehrter Herr Christian Wulff,

ich schreibe Ihnen als dem Schirmherrn der Deutschen Multiplen Sklerose Gesellschaft (DMSG) und bitte Sie, Ihren Einfluß in dieser Gesellschaft geltend zu machen, um sie zu einer aufgeschlossenen Haltung gegenüber einem therapeutischen und wissenschaftlichen Ansatz zu bewegen, den sie bislang – ihrem Ärztlichen Beirat folgend - ablehnt.

Durch die Arbeit des italienischen Gefäßchirurgen Prof. Paolo Zamboni ist vor wenigen Jahren ein Zusammenhang zwischen venösen Obstruktionen und dem Krankheitsbild der MS in das Blickfeld von Forschern und Betroffenen gerückt worden. Entsprechende Beobachtungen waren im Laufe der Medizingeschichte seit Charcot zwar immer wieder einmal gemacht worden, gerieten allerdings auch stets wieder in Vergessenheit – was zu einem Teil daran gelegen haben wird, daß heute angewandte, diagnostische Techniken – insbesondere nicht-invasive, bildgebende Verfahren wie MRT und Sonographie – in der Vergangenheit nicht zur Verfügung standen und eine therapeutische Konsequenz aus solchen Beobachtungen schwerlich hätte gezogen werden können.

"Negative study" from Germany, UK and PDFs for Int Angiol. 2010 Apr;29(2) available

Last modified: 15.06.2010 - 18:55 CET Created: 15.06.2010 - simplex

PDFs are available for free of the Int Angiol. 2010 Apr;29(2) issue. Check out the previous article.
[doepp10a] Doepp F, Paul F, Valdueza JM, Schmierer K, Schreiber SJ: No cerebro-cervical venous congestion in patients with multiple sclerosis. Annals of Neurology. 2010. doi:10.1002/ana.22085. Article$
Department of Neurology, University Hospital Charité, Humboldt University, Berlin, Germany; Barts and The London Queen Mary School of Medicine & Dentistry, London, UK

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7 CCSVI research projects funded

Last modified: 13.06.2010 - 16:03 CET Created: 13.06.2010 - simplex

The MS societies of Canada and USA announced funding of seven CCSVI research projects!

Multiple Sclerosis Society of Canada, June 11, 2010
National Multiple Sclerosis Society, June 11, 2010

"Over $2.4 Million Committed to Support Seven Operating Grants to Explore the Relationship of CCSVI to Multiple Sclerosis."

FAQs about new CCSVI grants

[trial_wolinsky10a] Wolinsky J: CCSVI and its relationship to MS. University of Texas Health Science Center at Houston, USA. Info.

University of Texas Health Science Center at Houston, USA.

Abstract

replicating the ultrasound methods used by Dr. Zamboni to investigate the association of CCSVI with major clinical types of MS and in non-MS control groups. The team is also testing whether other imaging methods can confirm the ultrasound findings, while identifying the most reliable technique to screen for CCSVI.

Term/Amount: 7/1/10-6/30/12; $574,958

Project Details: Recent preliminary studies have suggested that a phenomenon called Chronic Cerebrospinal Venous Insufficiency (CCSVI), a reported abnormality in blood drainage from the brain and spinal cord, may contribute to nervous system damage in MS. This hypothesis has been put forth by Dr. Paolo Zamboni from the University of Ferrara in Italy. This pilot study warrants a subsequent larger and better controlled study to definitively evaluate the possible impact of CCSVI on the disease process in MS.
Dr. Wolinsky has assembled an expert team to increase our understanding of CCSVI. Using a comprehensive approach, this team will first attempt to replicate the ultrasound methods used by Dr. Zamboni in 100 people with all major clinical types of MS, compared with 175 people in various non-MS control groups. Then, they are seeking to determine whether the findings are validated by noninvasive imaging techniques, such as an MRI machine using a powerful magnet. The team includes experts in MS, as well as experts from other fields such as vascular disease and venous imaging.
Validating a reliable diagnostic approach and demonstrating that CCSVI is specific to MS and contributes to disease activity would be necessary first steps before controlled therapeutic trials may be attempted.

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CTV News MS vein theory has roots in rejected research

Last modified: 11.04.2010 - 10:14 CET Created: 11.04.2010 - simplex

CTV News 09.04.10: MS vein theory has roots in rejected research (1:59)
Demand for a controversial treatment for multiple sclerosis is building in Canada. With prospective patients waiting for the treatment to go through testing, revelations have emerged that a similar therapy could have been tested years ago.